H5N1 highly pathogenic avian influenza virus isolated from conjunctiva of a whooper swan with neurological signs.

TitleH5N1 highly pathogenic avian influenza virus isolated from conjunctiva of a whooper swan with neurological signs.
Publication TypeJournal Article
Year of Publication2013
AuthorsBui VN, Ogawa H, Ngo LH, Baatartsogt T, Abao LNB, Tamaki S, Saito K, Watanabe Y, Runstadler J, Imai K
JournalArch Virol
Volume158
Issue2
Pagination451-5
Date Published2013 Feb
ISSN1432-8798
KeywordsAnimals, Bird Diseases, Birds, Cluster Analysis, Conjunctiva, Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H5N1 Subtype, Influenza in Birds, Japan, Molecular Sequence Data, Nervous System Diseases, Phylogeny, Sequence Analysis, DNA, Trachea, Viral Load
Abstract

<p>An H5N1 highly pathogenic avian influenza virus was isolated from conjunctiva of a whooper swan with neurological signs, which was captured during the latest H5N1 HPAI outbreak in Japan. The conjunctival swab contained a larger amount of the virus in comparison with the tracheal swab. This is the first report on H5N1 virus isolation from the conjunctiva of a wild bird, and the result may suggest the conjunctival swab to be a critical sample for H5N1 HPAIV detection in waterfowl. Phylogenetic analysis of the HA gene indicated that the virus falls into H5N1 clade 2.3.2.1.</p>

DOI10.1007/s00705-012-1502-9
Alternate JournalArch. Virol.
PubMed ID23053526
Grant ListP30 ES002109 / ES / NIEHS NIH HHS / United States