Hemagglutinin Receptor Binding of a Human Isolate of Influenza A(H10N8) Virus.

TitleHemagglutinin Receptor Binding of a Human Isolate of Influenza A(H10N8) Virus.
Publication TypeJournal Article
Year of Publication2015
AuthorsRamos I, Mansour M, Wohlbold TJ, Ermler ME, Hirsh A, Runstadler JA, Fernandez-Sesma A, Krammer F
JournalEmerg Infect Dis
Volume21
Issue7
Pagination1197-201
Date Published2015 Jul
ISSN1080-6059
KeywordsAnimals, Cell Line, Tumor, Dogs, Hemagglutinins, Humans, Influenza A Virus, H10N8 Subtype, Madin Darby Canine Kidney Cells, Protein Binding, Receptors, Virus, Virus Attachment, Virus Replication
Abstract

<p>Three cases of influenza A(H10N8) virus infection in humans have been reported; 2 of these infected persons died. Characterization of the receptor binding pattern of H10 hemagglutinin from avian and human isolates showed that both interact weakly with human-like receptors and maintain strong affinity for avian-like receptors.</p>

DOI10.3201/eid2107.141755
Alternate JournalEmerging Infect. Dis.
PubMed ID26079843
PubMed Central IDPMC4480385
Grant ListHHSN272201400008C / / PHS HHS / United States
T32 AI078892 / AI / NIAID NIH HHS / United States
T32 AI788926 / AI / NIAID NIH HHS / United States